CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes
نویسندگان
چکیده
Presentation of peptide:MHCII by RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms.
منابع مشابه
CCR7-dependent trafficking of RORgþ ILCs creates a unique microenvironment within mucosal draining lymph nodes
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Corrigendum: CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes
Previous work by Tomura et al. reporting the generation and use of Kaede transgenic mice was inadvertently omitted from the reference list of this article and should have been cited at instances where these mice are referred to. For example, in the Results section, Tomura et al. should have been cited as follows: ‘Since ILC3s are concentrated within the gut, we sought to test whether an ILC3 bi...
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